Biol. Pharm. Bull.

Biol. Pharm. Bull., 24(9),1091-1092, September 2001

Notes

The Suppressive Effect of Mangiferin with Exercise on Blood Lipids in Type 2 Diabetes

Toshihiro MIURA,^*,a Naoki IWAMOTO,^a Motoshi KATO,^a Hiroyuki ICHIKI,^c Masayoshi KUBO,^c Yasuhiro KOMATSU,^c Torao ISHIDA,^b Minoru OKADA,^c and Keiichiro TANIGAWA^a

Department of Clinical Nutrition,^a Hi-tech Research Center,^b Suzuka University of Medical Science, 1001–1 Kishioka,Suzuka, Mie 510–0293, Japan and Tsumura Central Research Laboratories, Tsumura and Co.,^c 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300–1100, Japan.

The effect of mangiferin (MF) with exercise on bood lipids was studied in KK-A^y mice, an animal model of type 2 diabetes. MF (30 mg/kg) reduced the blood cholesterol (p<0.05) and triglyceride level (p<0.01) of KK-A^y mice with exercise 2 weeks after oral administration when compared with the control group. Diabetes also often has elevated lipid levels. Therefore, it may be that MF has beneficial effects on hyperlipidemia in type 2 diabetes.

Key words mangiferin; hypolipidemic effect; type 2 diabetes

Notes

The Suppressive Effect of Mangiferin with Exercise on Blood Lipids in Type 2 Diabetes

Toshihiro MIURA,*,a Naoki IWAMOTO,a Motoshi KATO,a Hiroyuki ICHIKI,c Masayoshi KUBO,c Yasuhiro KOMATSU,c Torao ISHIDA,b Minoru OKADA,c and Keiichiro TANIGAWAa

Department of Clinical Nutrition,a Hi-tech Research Center,b Suzuka University of Medical Science, 1001–1 Kishioka,Suzuka, Mie 510–0293, Japan and Tsumura Central Research Laboratories, Tsumura and Co.,c 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300–1100, Japan.

Toshihiro MIURA,^*,a Naoki IWAMOTO,^a Motoshi KATO,^a Hiroyuki ICHIKI,^c Masayoshi KUBO,^c Yasuhiro KOMATSU,^c Torao ISHIDA,^b Minoru OKADA,^c and Keiichiro TANIGAWA^a

Department of Clinical Nutrition,^a Hi-tech Research Center,^b Suzuka University of Medical Science, 1001–1 Kishioka,Suzuka, Mie 510–0293, Japan and Tsumura Central Research Laboratories, Tsumura and Co.,^c 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300–1100, Japan.