Biol. Pharm. Bull., 24(9),1009-1011, September 2001
Regular Articles
Antidiabetic Activity of the Rhizoma of Anemarrhena asphodeloides and Active Components, Mangiferin and Its Glucoside
Toshihiro MIURA,*,a Hiroyuki ICHIKI,c Naoki IWAMOTO,a Motoshi KATO,a Masayoshi KUBO,c Hiroshi SASAKI,c Minoru OKADA,c Torao ISHIDA,d Yutaka SEINO,b and Keiichiro TANIGAWAa
Department of Clinical Nutrition, Suzuka University of Medical Science,a 1001–1 Kishioka, Suzuka, Mie 510–0293, Japan, Department of Metabolism and Clinical Nutrition, Kyoto University School of Medicine,b 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606–0123, Japan, Tsumura Central Research Laboratories, Tsumura and Co.,c 3586 Yoshiwara, Amimachi, Inashiki-gun, Ibaraki 300–11, Japan, and Hi-tech Research Center, Suzuka University of Medical Science,d 1001–1 Kishioka, Suzuka, Mie, 510–0293, Japan.
The antidiabetic activity of the rhizoma of Anemarrhena asphodeloides was investigated in KK-Ay mice, an animal model of genetic type 2 diabetes. The water extract of the rhizoma (AA) (90 mg/kg) reduced blood glucose levels from 5706±29 to 401±59 mg/dl 7 h after oral administration (p<0.05) and also tended to reduce serum insulin levels in KK-Ay mice. AA-treated KK-Ay mice had significantly reduced blood glucose levels in an insulin tolerance test. Based on these results, the antidiabetic mechanism of AA may be due to decreased insulin resistance. In addition, the active components of AA were confirmed to be mangiferin and its glucoside.
Key words
Anemarrhena asphodeloides; mangiferin; antidiabetic activity; KK-Ay mouse